Klinische studies acute myeloïde leukemie (AML)

Onbehandelde patiënten

cAMeLot-2 (75276617AML3001)

A Phase 3 Randomized, Double-blind, Placebo-controlled, Study of Bleximenib, Venetoclax and Azacitidine for the Treatment of Participants with Newly Diagnosed Acute Myeloid Leukemia Harboring KMT2A Rearrangements or NPM1 Mutations who are Ineligible for Intensive Chemotherapy

• Principal investigator: prof. dr. Johan Maertens
• More information: NCT06852222
• Internal reference number: S70109

Hovon 177 (EVOLVE-2)

Randomized study assessing azacitidine and venetoclax with or without revumenib in adult patients with newly diagnosed NPM1 mutated or KMT2A rearranged AML ineligible for intensive chemotherapy

• Principal investigator: prof. dr. Johan Maertens
• More information: NCT06652438
• Internal reference number: S70299

Hovon 173 (EVOLVE-1)

Ivosidenib and Azacitidine With or Without Venetoclax in Adult Patients With Newly Diagnosed IDH1-Mutated AML or MDS/AML Considered Ineligible for Intensive Chemotherapy

• Principal investigator: prof. dr. Johan Maertens
• More information: NCT07075016
• Internal reference number: S70027

Hovon 181

A Phase II multicenter study to assess the tolerability and efficacy of the addition of Bevacizumab to standard induction therapy in AML and high risk MDS above 60 years

• Principal investigator: Prof. Dr. Johan Maertens
• More information: NCT07223814
• Internal reference number: S71479

Behandelde patiënten

DSP-5336-101 (on hold)

A Phase 1/2, Open-Label, Dose-Escalation, Dose-Expansion Study of DSP-5336 in Adult Acute Leukemia Patients with and without Mixed Lineage Leukemia (MLL)-rearrangement or Nucleophosmin 1 (NPM1) Mutation

• Principal investigator: prof. dr. Johan Maertens
• More information: NCT04988555
• Internal reference number: S67836

95804306EDI1001

A Phase 1, First-in-human, Dose Escalation Study of JNJ-95804306 for Relapsed or Refractory Hematological Malignancies

• Principal investigator: Prof. Dr. Mariëlle Beckers
• More information: NCT07572006
• Internal reference number: S71895