Association between coronary perfusion parameters during hypothermic oxygenated perfusion and clinical outcomes after heart transplantation
Name of data controller: UZ Leuven
S-number: S71917
Description and purpose of the study
Both the European multicenter study on non-ischemic hypothermic perfusion (NIHP; NCT03991923) and the Australian-New Zealand study on hypothermic oxygenated perfusion (HOPE; ACTRN12620000595910) have demonstrated that hypothermic oxygenated perfusion (HOPE) may help preserve donor hearts for longer and potentially improve their quality prior to heart transplantation. The studies show that this preservation method is at least as effective as the conventional preservation method. Nevertheless, important questions remain regarding the optimal application of HOPE.
At present, there is a need for clear and easily applicable guidelines on what the coronary blood flow of a donor heart should normally look like during HOPE. In addition, we do not yet have a reliable method for assessing during this treatment whether a donor heart is of good quality and how well it will function after transplantation.
By combining the data from the two aforementioned studies, we have access to a large and representative dataset. This will allow us to investigate whether these questions can be answered.
The aim of this study is to investigate the normal pattern of coronary blood flow in a donor heart during HOPE. In addition, we aim to identify measurements that deviate from the normal pattern and to investigate whether donor characteristics and/or recipient outcomes are associated with coronary blood flow during this treatment.
Name study team: Gert-Jan Eerdekens
Email address study team: gert-jan.eerdekens@uzleuven.be