Skin prick test: stop taking antihistamines in good time

You will soon be having a skin prick test to check for possible allergies. Read on to find out which medicines you need to stop taking 3 to 5 days before the test and which ones you can continue to take. This will help ensure a reliable test result.

How does a skin prick test work?

For the skin prick test, we use the automated SPAT (Skin Prick Automated Test) device. Small drops of allergens are applied to the forearm, followed by a small prick to allow them to enter the skin.

Stop taking antihistamines 3 to 5 days before the test

In order to obtain a reliable test result, it is important that you stop taking anti-allergy medication (antihistamines) 3 to 5 days before the skin prick test.

Antihistamines are medicines used to treat allergies. They suppress allergic reactions and can therefore cause the skin prick test to show no allergic reaction when one is actually present (false negative result).

Below is a list of medications that you must be stopped 3 to 5 days in advance.

Are you taking any of these medicines? If so, discuss with your physician how you can stop taking them safely and in good time.

Which medication should you stop taking?

Brand nameActive ingredient
AeriusDesloratadine
AllegratabFexofenadine
ArlevertanCinnarizine + dimenhydrinate
AtaraxHydroxyzine
BellozalBilastine
CetirizineCetirizine
DesloratadineDesloratadine
EbastineEbastine
EstivanEbastine
FenistilDimetindene
KetotifenKetotifen (intake not recommended in asthma!)
LevocetirizineLevocetirizine
LoratadineLoratadine
MizotifenMizolastine
NavalitDoxylamine + pyridoxine
R Calm DimenhydrinateDimenhydrinate
RupatadineRupatadine
RupatallRupatadine
TelfastFexofenadine
XyzallLevocetirizine
ZaditenKetotifen (intake not recommended in asthma!)
ZyrtecCetirizine
AerinazePseudoephedrine + desloratadine
CirrusPseudoephedrine + cetirizine
ClarinasePseudoephedrine + loratadine
Rhinathiol AntirhinitisPhenylephrine + chlorphenamine
RhinosinutabPseudoephedrine + cetirizine
RhinofebrylParacetamol + chlorphenamine

Which medication do you not need to stop taking?

You do not need to stop taking the following medication:

  • inhalation therapy for asthma, such as puffs
  • nasal sprays
  • eye drops
  • stomach-protecting medication

These medicines are not H1 antihistamines and do not affect the skin prick test.

Have you had a skin prick test in the last 5 years?

If so, please contact your treating physician. It may not be necessary to repeat the skin prick test.

Last edit: 6 october 2026