New blood vessels
The researchers also discovered that COVID-19 also caused the growth of numerous new blood vessels (angiogenesis). This became apparebt with the help of advanced imaging techniques and molecular research. In addition, COVID-19 appeared to cause a specific infection process in the lungs, different from that of any influenza virus.
Dr. Stijn Verleden (postdoctoral researchers in the BREATHE research group): "This research shows that the damage to the pulmonary veins played an important part in the respiratory failure and the unique clinical image (ARDS or acute respiratory distress syndrome) of COVID-19. This brings important new insights for the development of innovative therapies, specifically aimed at preventing or healing these vascular deviations."
The research is the result of a worldwide international collaboration of research groups in Germany (Hannover, Mainz), Belgium (Leuven), Switzerland (Basel) and the USA (Cambridge, Harvard). The respiratory diseases department and the thoracic surgery department of UZ Leuven and the KU Leuven research group BREATHE (Lab for Respiratory Diseases and Thoracic Surery) were closely involved in the research. The results of the trial were recently published in the renowned journal ‘The New England Journal Of Medicine’.