UZ Leuven

 Research projecten

 

Working memory in children : ERP study

2002-2011

L. Lagae PI

Ivan Myatchin, doctoral student KUL

  

Miniature wireless EEG

IMEC-nl research project, together with ESAT

L. Lagae PI

 

Multimodal monitoring of electrophysological signals in childhood epilepsy and cortically all newborns

IMEC-nl

L. Lagae PI

Katrien Jansen, doctoral student

  

Automated seizure detection with accelerometers

IWT- TBM project in collaboration with Mobilab, Katholieke Hogeschool Kempen en Pulderbos Epilepsycenter

L. Lagae

Kris Cuppens

 

Automated Video detection of seizures

TBM project in collaboration with Mobilab, Katholieke Hogeschool Kempen en Pulderbos Epilepsycenter

L. Lagae

Kris Cuppens

  

Neuro-connectivity of speech development in children

KUL project postdoc

L. Lagae PI

Nathalie Rommel

Marjolein Verhy

 

Anti-epileptic Drug trials phase 2 and 3

* Zonisamide in childhood epilepsy (Eisai)

* Perampanel in partial epilepsy (Eisai)

* Lacosomide in young children (USB)

* Pregabalin in childhood epilepsy

L. Lagae PI

 

European Registry for Epilepsy below the age of 'year (EPNS)

L. Lagae PI

 

Cost - effectiveness of ketogenic diet in childhood epilepsy

L. Lagae PI, L. Régal co-PI

 

European study of VNS efficacy in childhood epilepsy

L. Lagae PI

 

Everolimus in tuberous sclerosis

L. Lagae PI

Liesbeth De Wale co-Pi

 

Early detection of cardiomyopathy in Duchenne muscular dystrophy (introduction and use of tissue doppler imaging to assess myocardial (dys)function in patients with muscular dystrophy; collaborative project with pediatric cardiology

2004 – current

G. Buyse PI

 

SNT-II-001-E clinical trial (phase 2 extension of Delphi trial) : A Phase II open-label extension study to obtain long-term safety, tolerability and efficacy data of Idebenone in the treatment of Duchenne Muscular Dystrophy

08/2008 – current

G. Buyse PI

 

SNT-III-003 (DELOS) clinical trial : A Multicenter International Phase III double-blind, randomized, placebo-controlled study of the efficacy, safety and tolerability of idebenone in 10 – 18 year old patients with Duchenne muscular dystrophy

08/2009 - current

G. Buyse PI, N. Goemans co-PI

 

Combined use of NIRS (near-infrared spectroscopy) and EMG in Duchenne muscular dystrophy

Collaborative project with ESAT KU Leuven

2009 – current

G. Buyse PI

 

6-minutenwandeltest bij gezonde Caucasische jongens

Buyse G, Goemans N; samenwerking met faculteit FABER (Feys H, Klingels K)

2009 – ongoing

 

Vergelijkende studie van meetschalen voor de grove motoriek bij jonge kinderen met Duchenne spierdystrofie

Buyse G, Goemans N; samenwerking met faculteit FABER (Feys H, Klingels K)

2012 - ongoing

 

Development of novel pharmaceutical and stem cell-based therapies for cardiomyopathy related to Duchenne muscular dystrophy

PhD project, Stamcelinstituut KU Leuven

11/2012 – ongoing

Promotor: C Verfaillie;  Co-promotor: G Buyse, M Sampaolesi

 

Development and characterisation of patient-specific induced pluripotent stem (iPS) cells for in vitro drug screening and disease modelling in Duchenne muscular dystrophy

PhD project, Stamcelinstituut KU Leuven

11/2012 – ongoing

Promotor: M Sampaolesi, Co-promotor: G Buyse, L Thorrez

 

Impact van plagiocefalie bij zuigelingen op de vorm van schedel op kleuterleeftijd

2008-2010

Eindwerk Jeugdgezondheidszorg, Promotor K. Hoppenbrouwers, Co-promotor E. Ortibus

 

Constructie  van een gestandaardiseerde testbatterij voor de diagnose van CVI in kinderen jonger dan 3 jaar.

2010-2012

E. Ortibus P.I.

 

Cytotect(R) Phase III trial in congenital cytomegalovirus (CMV) infection

2009-current

E. Ortibus P.I.

 

CINRG site coordinator Catholic University of Leuven

CINRG CNMC 0599: A multicenter randomised placebo controlled double blind study to assess efficacy and safety of glutamine and creatine monohydrate in Duchenne Mucular Dystrophy

CINRG KUL0401 An open label pilot study of Oxatomide in steroid naive Duchenne Muscular Dystrophy

CINRG UCD03050: A longitudinal study of the relationship between impairment , activity, limitation, participation and quality of life in persons with confirmed Duchenne muscular dystrophy (DMD)

Santhera study SNTII-1: Phase IIa double blind ,randomized, placebo controlled, single centre study at the university of Leuven to assess the efficacy and tolerability of idebenone in 10-16 year old males with cardiac dysfunction associated with Duchenne Muscular Dystrophy

N. Goemans co-PI

 

KUleuven:B32220072794

Studie van de fysische activiteit van kinderen met neuromusculaire aandoeningen door middel van kinematische metingen.

Hopital Universitaire de Lausanne

2008 - current

N. Goemans PI

 

Prosensa PRO 051- 02

A phase I/II open label escalating dose pilot study to assess the effect, safety, tolerability and pharmacokinetics of multiple subcutaneous doses of PRO051 in patients with Duchenne muscular dystrophy

2008 - current

N. Goemans PI

 

Prosensa PRO 051-02 Extension

A phase I/II open label pilot study to assess the long term effect, safety, tolerability and pharmacokinetics of multiple subcutaneous doses of PRO051 in patients with Duchenne muscular dystrophy

2009 - current

N. Goemans PI

 

Prosensa PRO 044-CLIN 01

A phase I/II open label escalating dose pilot study to assess the effect, safety, tolerability and pharmacokinetics of multiple subcutaneous doses of PRO044 in patients with Duchenne muscular dystrophy

2010 - current

N. Goemans PI

 

PTC 124- GD -007-DMD

A phase 2B Efficacy and Safety study of PTC124 in subjects with nonsense mutation mediated Duchenne and Becker dystrophy.

2008 - 2010

N. Goemans PI Benelux site

 

GSK - DMD114044 DEMAND III

A phase III randomized placebo controlled clinical study to assess efficacy and safety of GSK 2402968 in subjects with Duchenne muscular dystrophy

2010 - current

N. Goemans PI

 

B40320095819

Clinical, neurophysiological and electrophysiological study of cognitive function in patients with Duchenne muscular dystrophy.

2010 - 2011

N. Goemans PI

 

Effect of Idebenone on protoporphyrin IX, cardiac hypertrophy and cardiac function in Freidreich’s ataxia

KULeuven

N. Goemans co-PI

 

Early and prospective cardiac evaluation with heart strain and strain rate imaging in Duchenne Muscular

Porticus-KULeuven

N. Goemans co-PI

 

Glucose metabolism in patients with neuromuscular disorders

KULeuven Eudract 2006-004749-40

N. Goemans co-PI

 

A phase III, randomized, double blind, placebo-controlled clinical study to assess the efficacy and safety of GSK2402968 in subjects with Duchenne muscular dystrophy.

S52795

N. Goemans PI

   

Phase II, multicenter, randomized, adaptive, double-blind, placebo controlled study to assess safety and efficacy of olesoxime (TRO19622) in 3-25 year old Spinal Muscular Atrophy (SMA) patients.

S52565

N. Goemans PI

 

An open-label extension study of the long-term safety, tolerability and efficacy of GSK2402968 in subjects with Duchenne Muscular Dystrophy.

S53360

N. Goemans PI

 

An open-label study for previously treated ataluren (PTC124®) patients with nonsense mutation dystrophinopathy.

S54011

N. Goemans PI

 

A Prospective Natural History Study of progression of physical impairment, activity limitation and quality of life in Duchenne Muscular Dystrophy (DMD). 

S53808

N. Goemans PI

 

A phase IIb, open-label study to assess the efficacy, safety, pharmacodynamics and pharmacokinetics of multiple subcutaneous doses of PRO045 in subjects with Duchenne muscular dystrophy.

S54705

N. Goemans PI

 

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