UZ Leuven

Historiek Laboratorium voor Leverfysiopathologie

 Localisatie: initiëel Rega Instituut 3de: ex-dieren localen, later O&N 2, 7de verdieping. 

• Oct 1959: Dr Jan DeGroote komt terug uit Londen. Thesis : Levercoma: vorming van ammonia uit aminozuren
• 1960: Karel Heirwegh Dr Sci had zijn doctoraat behaald bij Prof Lontie (biochemie) over Haemocyanine en wordt benoemd in het labo. Interesse: Aminozuren, purines en pyrimidines
• 1962: Dr Frans Van Roy : klinisch bioloog komt werken en brengt zijn interesse binnen: bilirubine
• 1963: student Carlos Ramboer ( GSO-FWO in 1965) komt werken over purines
• 1964: Dr Johan Fevery (GSO-FWO in 1964) begint te werken over de glucuronidatie van paracetamol, later naar bilirubine.
• 1967: Dr Juul Meeuwissen: werkt op bindingseiwitten: gluthationtransferases
• 1968: Dr Herwig Jansen: glucuronidering van sulfamides
• 1969: Dr Norbert Blanckaert: vervoegt de bilirubine groep
• 1977: Dr Werner Van Steenbergen komt werken over de effecten van farmaca op bilirubine conjugatie.
• 1979:  Dr Florent Van Stapel werkt op de kinetica van bilirubine glucuronyltransferase: verschillende bilirubine substraten, mechanisme van microsomale glycosidatie en van transport van UDP-suikers doorheen de mircrosomiale membraan.
• 1986:  Marc Vermeir  komt de binding van anionen aan eiwitten bestuderen.
• 1989:  Dr Paul Yap (uit Nijmegen): studie van hepatitis virussen met Han Moshage (die in 1994 naar Groningen vertrekt) 
• 1990: Prof N Blanckaert  komt terug uit San Francisco en wordt hoofd van Laboratoriumgeneeskunde.
• 1993: Dr Van Stapel komt terug uit San Francisco en de subgroep van Prof Blanckaert met George Michiels en Greet Wuyts als laboranten wordt einde 1993 een research labo van Laboratoriumgeneeskunde.
• 2005: Gezamenlijk onderzoekseenheid gevormd met het doel om een breed translationeel lever onderzoeksplatform te zijn:

LIVER RESEARCH FACILITY 

Hierin werken samen: Labo Hepatologie (Prof van Pelt J, Prof Verslype, Prof Cassiman D, Prof Laleman W, Prof Nevens F), Labo Abdominale Transplantatie (Prof Pirenne, Prof Monbaliu), Urgentie Geneeskunde (Prof Wilmer, Prof Mesotte), Pathologie UZ Gent (Prof Libbrecht) en op project basis: Abdominale Chirurgie (Prof Topal), Hypertensie (Prof Petrov, Prof Lijnen), Pathologie KUL (Prof Roskams), Digestieve Oncologie (Prof Van Cutsem), ESAT (Prof De Moor) en VIB-Microarray Facility.  

Laboranten:

Van het eerste uur

• Lieve Spaas
• Roger Michiels vnl dierenproeven
• Martin Herroelen: afwasser, hulp bij de lessen laboratorium onderzoek ...
• Staf Van Hees & Roger Servaes: werken vnl met Prof Heirwegh (theorie en binding van anionen o.a. bilirubine)
• Pol Leroy & Mariette Van de Vijver werken met J Fevery: bilirubine glycosyltranserases in verschillende organen en bij verschillende dieren en bij hemolysen en leverziekten. Gal-en urine analyses voor bilirubine derivaten. Nieuwe analyse methodes: dunne laag chromatografie…
• Marc Kinnaert (+) en Marcel Zeegers: werken vnl bij J Meuwissen bindingseiwitten: isolatie en karakterisatie
• Roger Servaes ,Georges Michiels en Greta Wuyts met N Blanckaert : methodologie TLC en HPLC,  Bil-Albumine en glycolsyltransferasen
• Tina Crabbé, Christel Van den Eynden, Tamara Coopmans, 1990-2000
• Ingrid Vander Elst, Petra Windmolders, 2000- heden 

Buitenlandse onderzoekers:

• Giovanni L. Ricci : Effect of gastrointestinal polypeptide hormones on hepatic transport of bilirubin. 1983 
• Vital A. Mesa: Effect of organic anions on hepatic transport of bilirubin.1985 
• Maurizio Muraca: Studies on bilirubin conjugation en sex hormonen. 1986
• Stan Snowball:. Lincomycin treatment of guinea pigs causes formation of pigmented phosphate containing gallbladder sludge and stones. J Hepatol 1989;9:159-166.  en met G. Marchal, J. Fevery, S. Snowball,   A. Baert. The sonographic aspects of haemobilia. Eur J Radiol 1985;5:211-215.
• Klaus Kutz: (Klinische Farmakologie Bonn) : Kutz K, Kandler H, Gugler R, Fevery J.  Effect of clofibrate on metabolism of bilirubin, bromosulphophthalein and indocyanine green and on the biliary lipid composition in Gilbert's syndrome.  Clin Sci (Lond).  1984 Apr;66(4):389-97.
• Andreas Sieg: (Heidelberg) : Sieg A, Heirwegh KP, Fevery J, Raedsch R, Kommerell B. Similarities in maximal biliary bilirubin output in the normal rat after administration of unconjugated bilirubin or bilirubin diglucuronide.  Hepatology. 1989 Jul;10(1):14-20. en Sige A, van Hees GP, Heirwegh KP. Uridine diphosphate-glucoronic acid-independent conversion of bilirubin monoglucuronides to diglucuronide in presence of plasma membranes from rat liver is nonenzymic. J Clin Invest. 1982 Feb;69(2):347-57. en Sieg A, König R, Ullrich D, Fevery J. J Hepatol. 1990 1990 Sep;11(2):159-64. Subfractionation of serum bilirubins by alkaline methanolysis and thin-layer chromotography.  An aid in the differential diagnosis of icteric diseases.
• Dieter Ullrich (Göttingen&Heidelberg): Ullrich D, Tischler T, Sieg A, Fevery J. Renal clearance of bilirubin conjugates in newborns of different gestational age. Eur J Pediatr.1993 Oct;152(10):837-9. en Ullrich D, Fevery J, Sieg A, Tischler T, Bircher J.  The influence of gestational age on bilirubin conjugation in newborns.  Eur J Clin Invest. 1991 Feb;21(1):83-9.
• Petr Kotal: Urobilinogen-i is a major derivate of bilirubin in bile of homozygous Gunn rats. Biochem J 1990;268:181-185.  en Kotal,-P; Vitek,-L; Fevery,-J. Fasting-related hyperbilirubinemia in rats: the effect of decreased intestinal motility. Gastroenterology. 1996; 111: 217-23
• Zhao Ping: Chronic Pancreatitis. Development and evaluation of animal models in the cat. 1992.
• J. Gonzalez: Spontaneously diabetic biobreeding rats and impairment of bile acid-independent bile flow and increased biliary bilirubin, calcium and lipid secretion. Hepatology 1992;16:426-432.
• Siná Aziz: The nature of the bilirubin pigments in the newborn infant. 1995
• Andrej Kiassov (Rusland): Embryogenese. Kiassov AP, Van Eyken P, van Pelt JF, Depla E, Fevery J, Desmet VJ, Yap SH. Desmin expressing nonhematopoietic liver cells during rat liver development: an immunohistochemical and morphometric study.  Differentation.1995 Nov; 59(4):253-8.
• Vitek,-L; Kotal,-P; Jirsa,-M; Malina,-J; Cerna,-M; Chmelar,-D; Fevery,-J. Intestinal colonization leading to fecal urobilinoid excretion may play a role in the pathogenesis of neonatal jaundice. J-Pediatr-Gastroenterol-Nutr. 2000 Mar; 30(3): 294-8
• Anita K. Omasta: The functional consequences of in vivo gene transfer of endothelial nitric oxide synthase in the experimental rat model of cirrhotic portal hypertension. 2001

 Samenwerking met buitenlandse groepen

• J. Fevery, N. Blanckaert, K.P.M. Heirwegh, A.M. Préaux & P. Berthelot. Unconjugated bilirubin and an increased proportion of bilirubin monoconjugate in the bile of patients with Gilbert’s syndrome and Crigler-Najjar disease. J Clin Invest 1977;60:970-979.
• G. Duhamel, N. Blanckaert, J-M Metreau, A-M. Préaux, M. Bouvry, J. Fevery and P. Berthelot. An unusual case of Crigler-Najjar disease in the adult. Classification into Types I and II revisited.
  J Hepatol 1984;1:47-53.
• S. Erlinger, A. Le Go, J-M Husson and J. Fevery. Franco-Belgian cooperative study of ursodeoxycholic acid in the medical dissolution of gallstones. Hepatology 1984;4:308-314.
• K. Kutz, H. Kandler, R. Gugler and J. Fevery. Effect of clofibrate on the metabolism of bilirubin, bromosulphophtalein and indocyanine green and on the biliary lipid composition in Gilbert’s syndrome. Clin Science 1984;66:398-397.
• A. Sieg, A. Stiehl, K.P.M. Heirwegh, J. Fevery, R. Raedsch, B. Kommerell. Similarities in maximal biliary bilirubin output in the normal rat after administration of unconjugated bilirubin or bilirubin diglucuronide. Hepatology 1989;10:14-20.
• A. Sieg, R. König, D. Ullrich, J. Fevery Subfractionation of serum bilirubins by alkaline methanolysis and thin-layer chromatography.An aid in the differential diagnosis of icteric diseases.J Hepatol 1990;11:159-164.
• L. Okolicsanyi, J. Fevery, B. Billing, P. Berthelot, R.P.H. Thompson, R. Schmid and P.D. Berk. How should mild isolated unconjugated hyperbilirubinemia be investigated? Sem Liv Dis 1983;3:36-41.
• H.J. Schuurman, A.J.M. Vogten, S.W. Schalm, J. Fevery.  Clinical evaluation on the liver cell membrane. Autoantibody assay. Digestion 1982;23:184-193.
• F. Kuipers, M. Enserink, R. Havinga, Ad. Van der Steen, J. Hardonck, J. Fevery, R.J. Vonk.Separate transport systems for biliary secretion of sulfated and unsulfated bile acids in the rat. J Clin Invest 1988;81:1593-1599.
• D. Ullrich, J. Fevery, A. Sieg, T. Tischler, J. Bircher. The influence of gestational age on bilirubin conjugation in newborns. Eur J Clin Invest 1991;21:83-89.
• J. Rothuizen, W.E. van den Brom, J. Fevery. The origins and kinetics of bilirubin in healthy dogs, in comparison with man. J Hepatol 1992;15:25-34; en         in dogs with hepatobiliary and haemolytic diseases. J Hepatol 1992;15:17-24.
• S van der Merwe, van den Bogaerde JB, Goosen C, Maree FF, Milner RJ, Schnitzler CM, Biscardi A, Mesquita JM, Engelbrecht G, Kahn D, Fevery J.  Hepatic osteodystrophy in rats results mainly from portasystemic shunting. Gut. 2003 Apr;52(4):580-5.
• Noman MZ, Buart S, Van Pelt J, Richon C, Hasmim M, Leleu N, Suchorska WM, Jalil A, Lecluse Y, El Hage F, Giuliani M, Pichon C, Azzarone B, Mazure N, Romero P, Mami-Chouaib F, Chouaib S. The cooperative induction of hypoxia-inducible factor-1 alpha and STAT3 during hypoxia induced an impairment of tumor susceptibility to CTL-mediated cell lysis. J Immunol. 2009 Mar 15;182(6):3510-21
• Lassoued s, Gargouri B, El Feki Ael F, Atti H, Van Pelt J. Transcription of the esptein-barr virus lytic cycle activator BZLF-1 during oxidative stress inductio. Biol Trace Elem Res.2010 Oct;137(1):13-22. en Gargouri B, Van Pelt J, El Feki Ael F, Attia H, Lassoued S. Induction of Espstein-Barr virus (EBV) lytic cycle in vitro causes oxidative stress in lymphoblastoid B cell lines. Mol Cell Biochem. 2009 Apr;324(1-2):55-63. 

Samenwerking met andere afdelingen:

Pathologie :

• B. Van Damme, J. Fevery & K.P.M. Heirwegh. Altered composition of bilirubin conjugates in rat bile after obstruction of the common bile duct. Experienta 1971;26:27-28.
• J. Fevery, C. De Wolf-Peeters, R. De Vos, V. Desmet and K.P.M. Heirwegh. Perinatal development of bilirubin UDP-Glycosyltransferase activities in rat liver. Biol Neonate 1977;32:336-342.
• M.B. Ray, V.J. Desmet, J. Fevery, J. De Groote, A.F. Bradburne & J. Desmyter.Distribution patterns of hepatitis B surface antigen (HBsAg) in the liver of hepatitis patients. J Clin Pathol 1976;29:94-100.
• F. Callea, J. Fevery, G. Massi, C. Lievens, J. De Groote and V. Desmet. Alpha-1-antitrypsin (AAT) and its stimulation in the liver of PiMZ phenotype individuals. A “recruitment-secretory block” (“R-SB”) phenomenon. Liver 1984;4:325-337.
• J.J. Van den Oord, J. Fevery, J. De Groote and V.J. Desmet. Immunohistochemical characterization of inflammatory infiltrates in primary biliary cirrhosis. Liver 1984;4:264-274.
• R. Sciot, D. Staessen, W. Van Steenbergen, B. Van Damme, J. Fevery, J. De Groote, V. Desmet Incomplete septal cirrhosis, a clinico-pathological entity. Hepatology 1987;7:1160.
• Vander Borght S, van Pelt J, van Malenstein H, Cassiman D, Renard M, Verslype C, Libbrecht L, Roskams TA. Up-regulation of breast cancer resistance protein expression in hepatoblastoma following chemotherapy: A study in patients and in vitro. Hepatol Res. 2008;38(11):1112-21.
• Cassiman D, Sinelli N, Bockx I, Vander Borght S, Petersen B, De Vos R, van Pelt J, Nevens F, Libbrecht L, Roskams T. Human hepatic progenitor cells express vasoactive intestinal peptide receptor type 2 and receive nerve endings. Liver Int. 2007 Apr;27(3):323-8.
• Libbrecht L, Severi T, Cassiman D, Vander Borght S, Pirenne J, Nevens F, Verslype C, van Pelt J, Roskams T. Glypican-3 expression distinguishes small hepatocellular carcinomas from cirrhosis, dysplastic nodules, and focal nodular hyperplasia-like nodules. Am J Surg Pathol. 2006 Nov;30(11):1405-11.

Virologie :

• Lin L, Libbrecht L, Verbeeck J, Verslype C, Roskams T, van Pelt J, Van Ranst M, Fevery J. Quantitation of replication of the HCV genome in human livers with end-stage cirrhosis by strand-specific real-time RT-PCR assays: methods and clinical relevance. J Med Virol. 2009 Sep;81(9):1569-75.
• Severi T, Ying C, Vermeesch JR, Cassiman D, Cnops L, Verslype C, Fevery J, Arckens L, Neyts J, van Pelt JF. Hepatitis B virus replication causes oxidative stress in HepAD38 liver cells. Mol Cell Biochem. 2006 Oct;290(1-2):79-85.
• Verbeeck, J., Van Ranst, M. (sup.), Nevens, F. (cosup.), Lemey, P. (cosup.) (2010). Hepatitis C virus epidemiology and evolution of genotype 5a.

Anatomo pathologie:

• C. De Wolf-Peeters, R. De Vos, V. Desmet, M.B. Ray, J. Desmyter, G. De Groote, J. Fevery, L. Broeckaert & J. De Groote; Human non-A, non-B hepatitis: ultrastructural alternations in hepatocytes. Liver 1981;1:50-55.
• R. De Vos, C. De Wolf-Peeters, M.J. Van Stapel, F. Callea, G. De Groote, J. Desmyter, J. Mortelmans, J. Fevery. New ultrastructural marker in hepatocytes in nonA, non B viral hepatitis.Liver 1982;2:35-44.

Chirurgie:

• J. Fevery, W.Tanghe, R. Kerremans, V. Desmet & J. De Groote. Congenital dilatation of the intrahepatic bile ducts associated with the development of amyloidosis. Gut 1972;13:604-609.
• Topal B, Aerts JL, Roskams T, Fieuws S, Van Pelt J, Vandekerckhove P,Penninckx F. Cancer cell dissemination during curative surgery for colorectal liver metastases. Eur J Surg Oncol. 2005 Jun;31(5):506-11.
• Mariani PP, van Pelt JF, Ectors N, Topal B, D'Hoore A, Penninckx F. Rectal washout with cytotoxic solution can be extended to the whole colon. Br J Surg.2002 Dec;89(12):1540-4.

Hematologie:

• J. Fevery, R. Verwilghen, T.G. Tan & J. De Groote. Glucuronidation of bilirubin and the occurrence of pigment gallstones in patients with chronic haemolytic diseases. Eur J Clin Invest 1980;10:219-226.

Pharmacie:

• Ye ZW, Van Pelt J, Camus S, Snoeys J, Augustijns P, Annaert P.Species-specific interaction of HIV protease inhibitors with accumulation of cholyl-glycylamido-fluorescein (CGamF) in sandwich-cultured hepatocytes. J Pharm Sci. 2010 Jun;99(6):2886-98.

Gastroenterologie:

• Ph. Van Hootegem, P. Rutgeerts, J. Fevery, L. Broeckaert, J. De Groote and G. Vantrappen. Sclerotherapy of oesophageal varices after variceal haemorrhage.
  Endoscopy 1984;16:95-97.
• P. Rutgeerts, Y. Ghoos, G. Vantrappen, J. Fevery. Biliary lipid composition in patients with nonoperated Crohn’s Disease. Dig Dis Dc 1986;31:27-32. 

 Endocrinologie:

• R. Bouillon, J. Auwerx, L. Dekeyser, J. Fevery, W. Lissens and P. De Moor. Serum vitamin D metabolites and their binding protein in patients with liver cirrhosis. J Clin Endocr Met 1984;59:86-89.

Radiologie:

• G. Marchal, D. Crolla, A.L. Baert, J. Fevery & R. Kerremans Gallbladder wall thickening: a new sign of gallbladder disease visualized by gray scale cholecystonography. J Clin Ultrasound 1978;6:177-179.
• Y. Ni, G. Lukito, G. Marchal, E. Cresens, J. Yu, C. Petre, A.L. Baert, J. Fevery. Potential role of bile duct collaterals in the recovery of the biliary obstruction: experimental study in rats using microcholangiography, histology, serology and magnetic resonance imaging.Hepatology 1994;20:1557-1566.
• Maleux, G.(2008). Value of new diagnostic and interventional radiological tecnhiques to improve clinical outcome of transjugular intrahepatic portosystemic shunts.

Intensieve geneeskunde:

• van Malenstein H, Wauters J, Mesotten D, Langouche L, De Vos R, Wilmer A, van Pelt J. Molecular analysis of sepsis-induced changes in the liver: microarray study in a porcine model of acute fecal peritonitis with fluid resuscitation. Shock. 2010 Oct;34(4):427-36.
• Wauters J, Mesotten D, Van Zwam K, van Pelt J, Thiessen S, Dieudonné AS,Vander Borght S, Van den Berghe G, Wilmer A. The impact of resuscitated fecal peritonitis on the expression of the hepatic bile salt transporters in a porcine model. Shock. 2010 Nov;34(5):508-16.

Abdominale transplantatie:

• Monbaliu D, Vekemans K, Hoekstra H, Vaahtera L, Libbrecht L, Derveaux K,Parkkinen J, Liu Q, Heedfeld V, Wylin T, Deckx H, Zeegers M, Balligand E, Buurman W, van Pelt J, Porte RJ, Pirenne J. Multifactorial biological modulation of warm ischemia reperfusion injury in liver transplantation from non-heart-beating donors eliminates primary nonfunction and reduces bile salt toxicity. Ann Surg.2009 Nov;250(5):808-17.
• Monbaliu DR, Dubuisson CN, Zeegers MM, Crabbé MM, Fevery JM, Pirenne JM, van Pelt JF. Increased serum phospholipase A2 activity after non-heart-beating donor liver transplantation and association with ischemia-reperfusion injury. J Surg Res. 2009 Jan;151(1):125-31.

ESAT

• van Malenstein H, Gevaert O, Libbrecht L, Daemen A, Allemeersch J, Nevens F, Van Cutsem E, Cassiman D, De Moor B, Verslype C, van Pelt J. A seven-gene set associated with chronic hypoxia of prognostic importance in hepatocellular carcinoma. Clin Cancer Res. 2010 Aug 15;16(16):4278-88.

Hypertensie:

• Lijnen PJ, van Pelt JF, Fagard RH. Stimulation of Reactive Oxygen Species and Collagen Synthesis by Angiotensin II in Cardiac Fibroblasts. Cardiovasc Ther.2010 Jul 8.
• Lijnen P, Petrov V, van Pelt J, Fagard R. Inhibition of superoxide dismutase induces collagen production in cardiac fibroblasts. Am J Hypertens. 2008 Oct;21(10):1129-36.
• Petrov VV, van Pelt JF, Vermeesch JR, Van Duppen VJ, Vekemans K, Fagard RH, Lijnen PJ. TGF-beta1-induced cardiac myofibroblasts are nonproliferating functional cells carrying DNA damages. Exp Cell Res. 2008 Apr 5;314(7):1480.

Doctoraatsproefschriften:

• Jan De Groote: Onderzoek naar het ontstaan van levercoma. 1959
• Johan Fevery: Recent developments in bilirubin conjugation. 1972
• Herwig Jansen: Studies on bilirubin conjugation. 1972
• Carlos Ramboer: Purine and pyrimidine metabolism in patients with liver diseases. 1973
• Norbert Blanckaert: Biochemical aspects of bilirubin metabolism.1979
• Giovanni L. Ricci : Effect of gastrointestinal polypeptide hormones on hepatic transport of bilirubin. 1983
• Vital A. Mesa: Effect of organic anions on hepatic transport of bilirubin.1985
• Maurizio Muraca: Studies on bilirubin conjugation : Influence of  Sex hormonen. 1986
• Werner Van Steenbergen: Effects of UPD-glucuronosyltransferase and of bile flow on hepatic transport of bilirubin: In vivo and in vitro study in the rat. 1987
• Flor Van Stapel: Mechanistic aspects of esterification of bilirubin by the hepatic microsomal UDP-glycosyltransferase system. 1987
• Jules ATP Meuwissen: Transport of bilirubin-IXα in liver and blood : a biophysical and biochemical approach. 1984
• Marc Vermeir: Evaluation of lipophilic ligand interaction with reconstituted cytochrome P-450 and of methods for determination of membrane partition coefficients, 1992
• Zhao Ping: Chronic Pancreatitis. Development and evaluation of animal models in the cat. 1992
• Frederik Nevens:  Esophageal varices a major feature of portal hypertension: incidence, pathophysiology, diagnosis and treatment. 1994
• Marc Willems: Hepatitis C. Medical Virology and Experimental Study. 1994
• Kurt Hertogs: Isolation, molecular cloning and characterization of hepatitis B virus-binding protein on human liver plasma membranes. 1994
• Siná Aziz: On the nature of the bilirubin pigments in the newborn infant. 1995
• Jos van Pelt: Identification of human hepatocyte proteins which bind to intact Plasmodium falciparum sporozoites: involvement in sporozoite invasion into primary cultures of human hepatocyts. 1995
• Suwandhi Widjaja: Epidemiology of hepatitis B and hepatitis C infection in an urban area in Jakarta. A hospital and population based study. 1996
• Guy Van Roey: Pathogenesis of sodium retention and of ascites formation in experimental cirrhosis in rats. 1996
• Marc Van de Casteele: Involvement of nitric oxide and endothelium in the pathogenesis and treatment of portal hypertension. 1998
• Zuojiong Gong: In vitro infection of hepatitis B virus: direct involvement of human Annexin V and in vitro test system for the evaluation of antivrial drugs. 1998. 
• Genc Basha: Controlled killing of exfoliated colorectal cancer cells. 1998
• Li Sheng: Hepatitis G virus or GB virus C: a non-A-E hepatotropic virus? 1998
• Sandra De Meyer: Human Annexin V: characterization of the binding to HbsAg and the role in HBV infection. 1999
• Inge Fourneau: A potentially reversible model of acute liver failure in the pig: a model to test the efficiency of a bioartificial liver. 2001
• David Cassiman: The neural:neuroendocrine compartment of the liver: differentiation potential of the hepatic stellate cell. 2001
• Anita K. Omasta: The functional consequences of in vivo gene transfer of endothelial nitric oxide synthase in the experimental rat model of cirrhotic portal hypertension. 2001
• Chris Verslype: Detection of Hepatitis C virus-core and-envelope (E2) proteins in the liver. A tool to study patients with non-A to E Hepatitis. 2002
• Baki Topal: Colorectal liver metastases and cancer cell dissemination. 2003
• Wim Laleman: Role of hepatic stellate cells and vascular mediators in the pathophysiology of cirrhotic portal hypertension. 2006
• Diethard Monbaliu: Tolerance of livers to warm ischemia in a pre-clinical model of liver transplantation from non-heart-beating donors.2007
• Karen Pauwelyn: in vitro differentiation of pluripotent stem cells towards the hepatic lineage by mimicking embryonic and fetal liver development. 2009
• Lien van Landeghem: Vascular mediators in cirrhotic portal hypertension. 2009
• Ilse Bockx: Neurohepatology: the role of the vagus nerve in liver disease. 2010
• Aezam Katooni Zadeh: The role of liver progenitor cells in liver regeneration in acute and acute on chronic liver failure: a clinicopathological approach. 2010
• Tamara Severi: Progression of hepatocellular carcinoma: cellular changes, diagnostic parameters and therapeutic targets. 2010
• Peter Witters: Platelets, cholestatic liver disease and cystic fibrosis. 2010
• Hannah van Malenstein: Determination of prognosis in hepatocellular carcinoma.  The role of adaptive molecular mechanisms to microenvironmental factors. 2011
• Philip Roelandt: Hepatocytes and liver-specific non-parenchymal cells by differentation from human pluripotent stam cells. 2011

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