Results

Abdominal transplantsurgery and transplant coordination

Liver transplantation

Total numbers of liver transplants last 12 y. UZ Leuven (n= 615)

graphic total number of liver transplants last 12 y. UZ Leuven

Primary diagnosis for livertransplantation (n=615)

Indication	1997-2008		Patient survival
Viral hepatitis (Hepatitis C) (Hepatitis B) Viral hepatitis C without HCC Viral hepatitis B without HCC	21% (14%) (7%) 5% 5%	N=133 (N=89) (N=44) N=33 N=30	1 Jaar 94% 96% 97% 97%	5 jaar 80% 84% 97% 88%	10 jaar 62% 84% 70% 88%
Post alcoholic (with or without HCC) Post alcoholic without HCC	26% 19%	N=154 N=114	91% 92%	76% 80%	60% 75%
Cholestatic	9%	N=57	86%	79%	75%
Metabolic	8%	N=49	89%	83%	71%
Polycystic	6%	N=38	92%	88%	88%
Tumors(non HCC)	2%	N=8	100%	83%	53%
Congenital	2%	N=12	100%	100%	100%
Acute liver failure	9%	N=52	78%	75%	75%
Retransplantation	6%	N=39	80%	71%	71%
Other	11%	N=72	89%	79%	46%

Hepato cellular carcinoma related to the primary diagnosis (n=147)

Lab MELD and match MELD score at moment of transplantation

Age distribution of the liver transplant recipients 2008

Waiting time by Match Meld score for 2008

Meld 0-10: 408 days (median waiting time) - 1 patient - 408 days (min-max)
Meld 11-20: 152 days (median waiting time) - 8 patients - 19-449 days (min-max)
Meld 21-30: 126 days (median waiting time) - 38 patients - 6-1094 days (min-max)
Meld 31-40: 7 days (median waiting time) - 5 patients - 2-107 days (min-max)

Waiting time by bloodgroup and Match Meld score for 2008

Bloodgroup O: 408 days (Meld 0-10) - 223 days (Meld 11-20) - 160 days (Meld 21-30) - 54 days (Meld 31-40)
Bloodgroup A: no patients (Meld 0-10) - 166 days (Meld 11-20) - 110 days (Meld 21-30) - 7 days (Meld 31-40)
Bloodgroup B: no patients (Meld 0-10) - 138 days (Meld 11-20) - 103 days (Meld 21-30) - no patients (Meld 31-40)
Bloodgroup AB: no patients (Meld 0-10) - 19 days (Meld 11-20) - no patients (Meld 21-30) - no patients (Meld 31-40)

Evolution of patients on the liver waiting list at 31/12/2008; UZ Leuven versus other in Belgium

Total of patients deceased on waiting list, compared with total of registrations on the waiting list

10 years patient survival (1997-2008) (over the last 12 years) (all indications) UZ Leuven (n=615 transplantations in 576 patients) compared with Eurotransplant (1997-2008) (n=10055)

graphic 10 years patient survival (1997-2008) (over the last 12 years) (all indications) UZ Leuven (n=615 transplantations in 576 patients) compared with Eurotransplant (1997-2008) (n=10055)

10 years patient survival (1997-2008) (over the last 12 year) UZ Leuven elective patients (n=523) compared with acute patients (n=52)

Patient survival with HCC (primary diagnosis associated with HCC) (n=143) or no HCC (n=372)

10 years patient survival (1997-2008) (over the past 12 years) multivisceral against solid liver transplant

5 years patient survival transplanted with a donorliver older then 70 y. compared with younger then 70 y.

5 years patient survival compared with graft survival for livers from non heart beating donors

2 years survival in function of MELD score

Intestinal transplantation

In October 2000 and in June 2002, two patients suffering from the short bowel syndrome and TPN-induced liver failure have undergone a combined liver-duodenum-pancreas intestinal transplant. These patients are doing well respectively 8.5 and 7.5 years posttransplant. Until today, those patients have not developed any rejection episode and the intestinal function is correct. Those patients are living a normal life.

In November and December 2004, a third liver-duodenum-pancreas intestinal transplant was done in a 2-year-old boy and a first isolated intestinal transplant was performed in a 26-year-old female. Those two patients are doing well after respectively 4 and 5 years posttransplant. There was no rejection.

In 2007, three intestinal transplants were done. One patient received a combined intestinal and kidney transplantation and is doing well after 2 years posttransplant. There was no rejection. One patient received a liver-stomach-duodenum-pancreas intestinal transplant. He succumbed to an intracranial bleeding four months posttransplant. Finally, one patient received a partial intestinal transplant. In this case the donor was a living donor (the mother of the patient) in whom 2 m of distal ileum was procured. The donor is doing well. The graft was resected after 7 months post transplant due to acute and chronic rejection. The patient is doing well, however Total Parenteral Nutrition is necessary and we consider a retransplantation.

In 2008, two intestinal transplants were donr. One for combined liver-duodenum-pancreas intestinal transplant. This patient is going well and there was no rejection 8 months posttransplant. The other one was for isolated intestinal transplant. This patient died due to apergillus infection 6 months posttransplant.

Three months patient survival in this series of 9 consecutive intestinal transplantations (between 2000 and 2008) is 100%. Two patients died due to apergillus infection after more then 3 months posttransplant. Global patient survival (follow up: 8 months - 8.5 years) is 77.7%. This is much better compared with the results of the International Transplant Registry (50% patient survival 5 years posttransplant).

Begin of 2009, one patient is listed for isolated intestinal transplant.

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